WebJan 1, 2024 · In addition, the expression of BmFoxO was altered, and it was found that reduced expression of BmFoxO (dsBmFoxO) downregulated the expression of BmPEPCK-2 and increased the viral fluorescence and content in silkworm embryonic cell line BmE cells, and vice versa. BmFoxO could upregulate the expression of BmPEPCK-2 by binding to … WebApr 13, 2013 · GRP78 (78 kDa glucose-regulated protein), also known as BiP (immunoglobulin heavy-chain-binding protein), is an essential regulator of endoplasmic reticulum (ER) homeostasis because of its multiple functions in protein folding, ER calcium binding, and controlling of the activation of transmembrane ER stress sensors. In this …

果蝇中影响dFOXO调控寿命功能的相关基因的鉴定 - CNKI

WebOct 24, 2015 · Rhodiola rosea increased the expression of BmFoxO, which is a downstream regulator of insulin/IGF-1 signaling (IIS) pathway in the silkworm. Our results showed that R. rosea extends lifespan, in which IIS pathway might be involved, and enhances stress resistance in the silkworm. Thus, the silkworm might be used as a novel animal model for ... WebDepletion of BmFOXO induced the expression of genes coding for JH degradation enzymes suggesting that FOXO is likely involved in repression of JH degradation genes, and … trilogy automotive

TheFOXOtranscriptionfactorcontrolsinsectgrowth ...

Web果蝇中影响dFOXO调控寿命功能的相关基因的鉴定. 【摘要】： Foxo作为转录调节因子家族中的一员,可参与多条重要的信号通路,介导下游靶基因的转录表达,从而在细胞分化、代 … Web而人类目前只有2个长寿基因，FOXO3a和ApoE，很多抗衰老策略在复杂的衰老信号网络背景下，可能并不能影响FOXO3和ApoE的作用，因此难以延长人的寿命。. 此外，FOXO作 … Web4.BmFoxO的靶基因筛选及其对寿命的影响BmFoxO表达水平的升高能够显著延长家蚕个体寿命已经得到了证实,然而其延长寿命的分子机制仍需要进一步研究。 由于BmFoxO属于转录因子,其在执行功能过程中需要通过调节下游靶基因的转录活性来实现,因此FoxO下游靶基因的 ... trilogy auto detailing