WebThe 4T1 mouse mammary tumour cell line is a model of breast cancer, which is able to metastasize to site affected in human breast cancer. In 1983, Fred Miller and coworkers isolated the 4T1 mammary mouse carcinoma cell line from BALB/c mammary tumour. WebNov 21, 2024 · Bromelain and cisplatin both positively reduced the tumor size and lung metastasis of 4T1-challenged mice. However, regulation of tumor inflammation by bromelain and cisplatin are different, whereas bromelain showed an anti-inflammation effect while cisplatin was observed with a pro-inflammation effect.
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WebCisplatin is also used alone or in combination with other medications to treat bladder cancer that can not be treated with surgery or radiation therapy alone. Cisplatin is in a class of … WebNational Center for Biotechnology Information how to set up pools in epic
Influence of pH on the cytotoxicity of cisplatin in EMT6 mouse
WebDec 25, 2024 · We determined the dose and time dependent cytotoxicity of cisplatin on 4T1 cells by the xCelligence real-time electronic sensing assay. Cisplatin treatment reduced tumor growth, number of lung metastasis, and the splenomegaly of 4T1 tumor bearing mice. We showed that cisplatin inhibited the tumor stroma formation, the polarization of … WebAs expected, cisplatin decreased the lung metastasis score, whereas SRT1720 increased metastasis irrespective of cisplatin. In the primary tumors, cisplatin suppressed the mRNA level of angiopoietin-like protein 4 (angptl4), a lung metastasis-promoting gene product of breast cancer, but SRT1720 reduced the effectiveness of cisplatin. WebApr 29, 2015 · Cisplatin (DDP)-based chemotherapy is an important part of the multimodality treatment for head and neck cancers [ 4, 5 ]. However, intrinsic and acquired resistance to DDP is common in HSCC treatment, and the effectiveness of chemotherapy is often severely compromised [ 6 ]. how to set up pop email in outlook 365