Hirschsprung's disease (HD or HSCR) is a birth defect in which nerves are missing from parts of the intestine. The most prominent symptom is constipation. Other symptoms may include vomiting, abdominal pain, diarrhea and slow growth. Most children develop signs and symptoms shortly after birth. However, … See more Typically, Hirschsprung disease is diagnosed shortly after birth, although it may develop well into adulthood, because of the presence of megacolon, or because the baby fails to pass the first stool (meconium) … See more During normal prenatal development, cells from the neural crest migrate into the large intestine (colon) to form the networks of nerves called the myenteric plexus (Auerbach plexus) (between the smooth muscle layers of the gastrointestinal tract wall) and the See more Treatment of Hirschsprung's disease consists of surgical removal (resection) of the abnormal section of the colon, followed by See more The first report of Hirschsprung's disease dates to 1691, when it was described by Dutch anatomist Frederik Ruysch. However, the … See more The disorder may occur by itself or in association with other genetic disorders such as Down syndrome. About half of isolated cases are … See more Definitive diagnosis is made by suction biopsy of the distally narrowed segment. A histologic examination of the tissue would show a lack of ganglionic nerve cells. Diagnostic techniques involve anorectal manometry, barium enema, and rectal biopsy. … See more According to a 1984 study conducted in Maryland, Hirschsprung's disease appears in 18.6 per 100,000 live births. In Japan, it occurs at a similar rate of about one in 5,000 births (20 per 100,000). It is more common in male than female (4.32:1) and in white rather than … See more WebOct 1, 2024 · Hirschsprungs disease; Megacolon, congenital; Clinical Information. A congenital disorder characterized by the absence of myenteric ganglion cells in the …

Hirschsprung

WebFeb 4, 2024 · Hirschsprung disease (HD) is a congenital disorder defined by the absence of ganglion cells (GC) at the Meissner's plexus of the submucosa and Auerbach's … WebHirschsprung's disease (also called congenital aganglionic megacolon) occurs when some of your baby’s intestinal nerve cells (ganglion cells) don’t develop properly, delaying the … icd 10 code for laxative use

Automatic ganglion cell detection for improving the efficiency and ...

WebJan 14, 2024 · Diagnosing Hirschsprung disease by detecting intestinal ganglion cells using label-free hyperspectral microscopy Authors Marcos A Soares de Oliveira 1 , Laura Galganski 2 , Sarah Stokes 2 , Che -Wei Chang 1 , Christopher D Pivetti 2 , Bo Zhang 1 , Karen E Matsukuma 1 , Payam Saadai 3 4 , James W Chan 5 Affiliations WebThe identification of ganglion cells in Hirschsprung disease by the immunohistochemical detection of ret oncoprotein. The absence of ganglion cells (GCs) is the primary … WebIn Hirschsprung’s disease, the nerves that control these muscles (ganglion cells) are missing from part of the bowel. This means that faeces cannot be pushed through the bowel in the usual way. The length of the … money in 2002