Web11 Jan 2024 · Ferroptosis is a regulated form of cell death characterized by the accumulation of iron-dependent reactive oxygen species (ROS) and the depletion of plasma membrane polyunsaturated fatty acids (PUFAs), which is caused by the imbalance of … Web18 Aug 2024 · Mammalian TEAD proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. The Hippo pathway plays an essential role in controlling organ size and maintaining tissue homeostasis. Downstream from the Hippo …
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular ...
WebSodium-glucose cotransporter 2 (SGLT2) is highly expressed in RPTCs, but its relationship with YAP/TAZ in tubulointerstitial fibrosis ... From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. WebApelin-13 can slow down oxidative stress by inhibiting the PI3K/Akt signaling pathway in the rat HF model and ameliorate angiotensin II–induced cardiac insufficiency, impaired cardiac hemodynamics, and fibroblast fibrosis. 24 Hou and Li et al 25,26 showed that YAP/TAZ … proservice bmw
Context-dependent roles of YAP/TAZ in stem cell fates and cancer
Web21 Jun 2024 · Furthermore, YAP/TAZ transcriptional activation was inhibited when Rho was inhibited or the actin cytoskeleton was disrupted . RhoA activation increased the expression of YAP/TAZ and cell stiffness in HTM cells . These results indicate that the RhoA/ROCK … Web1 Dec 2024 · Long non-coding RNAs (lncRNAs) are a class of RNA transcripts that are longer than 200 nucleotides and have no apparent coding potential [8]. However, lncRNAs play a critical role in regulating the expression of many genes at the transcriptional, post … Webactivate the YAP/TAZ and promote ferroptosis. Finally, since the higher activity of YAP/TAZ promotes invasion and metastases and often associate with poor prognosis,our findings suggest that triggering ferroptosis may be valuable in a combinational therapy for these … research gathers necessary information