WebApr 11, 2024 · The small ubiquitin modifier-1 (SUMO-1) belongs to the family of ubiquitin-related proteins and is involved in the modulation of protein–protein interactions, as well as in post-translational modification processes (sumoylation). WebThe small ubiquitin-like modifier (SUMO) is a member of the ubiquitin-like superfamily, which consists of three family members in vertebrates (SUMO1-3) (for review, see Melchoir 2000; Alarcon-Vargas and Ronai 2002; Müller et al. 2004) and a single member (SMT3) in invertebrates (Schwarz et al. 1998).SUMO conjugation has been shown to affect …
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WebJun 13, 2009 · Although the majority of PIAS-interacting proteins are prone to modification by small ubiquitin-related modifier (SUMO) proteins and the PIAS proteins have the capacity to promote the modification as RING-type SUMO ligases, they do not function solely as SUMO E3 ligases. WebUsing these synthetic substrates we reveal that the SUMO domain enhances catalysis of SENP1, -2, -5, -6, and -7, demonstrating substrate-induced activation of SENPs by SUMOs. Small ubiquitin-related modifier (SUMO) 3The abbreviations used are: SUMO small ubiquitin-like modifier AFC 7-amino-4-trifluoromethyl coumarin DUB de-ubiquitinating … how deep is a crawl space
Mapping of SUMO sites and analysis of SUMOylation changes ... - PNAS
WebSmall ubiquitin-related modifier 4 Gene SUMO4 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 95 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function WebSUMO (small ubiquitin-related modifier) proteins are ∼ 10-kD polypeptides that function as reversible post-translational protein modifiers. They form isopeptide bonds with ɛ-amino … WebNov 6, 2024 · This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of … how deep is a cut to get stitches